Linda Resar

Professor, Departments of Medicine, Oncology, Pathology and Institute for Cellular Engineering, The Johns Hopkins University School of Medicine

Dr. Resar is recognized internationally for pioneering studies on High Mobility Group A (HMGA) proteins in development and cancer. Her laboratory engineered the first transgenic mouse model demonstrating that Hmga1 over-expression causes cancer in vivo. She also discovered that HMGA1 is a master regulator in stem cells and cancer. More recently, her group discovered a novel role for Hmga1 in maintaining both stem cells and their niche in intestinal epithelium by amplifying Wnt signals. This work is important because HMGA1 is highly expressed in stem cells and most aggressive cancers. She has published >80 manuscripts and currently holds 2 patents.