Loyal A. Goff

Assistant Professor of Neuroscience, Johns Hopkins University

Loyal Goff is an Assistant Professor of Neuroscience in the Institute of Genetic Medicine at Johns Hopkins University School of Medicine. The Goff Lab is focused on the identification and characterization of neural cell types, key cell fate decisions during development, and the effects of disease-associated mutations on these choices. We use bulk and single-cell measurements to characterize 1) neuronal subtypes during development, 2) identify functional relationships between transcriptional differences and physiological properties, 3) dissect the key cellular decisions that direct neural development and organization, and 4) identify where and how these events are misregulated during disease. Of particular interest to our group is the expanding role for the tissue and cell-type-specific long non-coding RNA molecules. We are interested in the mechanisms by which lncRNAs regulate target gene expression in the context of neuronal differentiation and maintenance of neuron identities